Background: A significant portion of women develops the biliary disease and its complication during pregnancy. Gallbladder disease is the second most common cause of non-obstetrics surgery after appendicectomy. Aim and Objectives: In this case series, we are trying the description of the various presentation of gallstone and its related complication during pregnancy and the postpartum period. Methods: The reported documents of 6 patients with complications of cholelithiasis during and after pregnancy, was collected after from hospital database from period 2016-2019. Results: In these 6 cases, 2 patients presented with acute cholecystitis at 30 and 15 weeks of gestation. Both of them were managed conservatively with antibiotics. The cholecystitis resolved and interval cholecystectomy was performed after delivery. Another 2 patients presented with acute cholecystitis during the 1st month of the post-partum period. These 2 patients were treated conservatively, and interval cholecystectomy was done after 6 weeks. Two patients with obstructive jaundice underwent endoscopic retrograde cholangiopancreatography (ERCP) and undergo interval cholecystectomy. Off 1 patient encountered post-ERCP complication. Despite complication ERCP followed by laparoscopic cholecystectomy is well available modality for common bile duct (CBD) stone with obstructive jaundice. Conservative management is the best way of treatment to avoid maternal and fetal morbidity and mortality. Conclusion: The conservative management of cholecystitis is a better way to treat during or immediately after pregnancy and interval cholecystectomy is a better line of management for cholecystitis pregnant patients. Although ERCP is having its complications, it is one of the best modality of extraction of CBD stones and followed by interval cholecystectomy later.