Chronic Kidney Disease__ampersandsignrdquo; also known as a chronic renal failure, is one of the major health problems today. The main function of the kidney in the human body is to filter the waste products of the human body and excrete the same in the form of urine. Infectious diseases are the second leading cause of morbidity and mortality in patients with chronic kidney disease, contributing around 30__ampersandsignndash;36% of deaths among patients on dialysis. Overall, this condition is a threat to the life of the patients, hence to improve in the patient__ampersandsignrsquo;s condition dialysis and renal replacement therapy is a must. But before the onset of dialysis and renal replacement therapy, here, early vaccination becomes must as a primary treatment modalities to prevent patients from nosocomial infections i.e. hospital-acquired infection like Hepatitis-B, Influenza, Pneumococcal diseases, these are the common diseases due to such infection and their prevalence rate is high in India as compared to others diseases. Therefore, to prevent the patients from any such risk early vaccination is needed. This review aimed to access this information for educating the patients regarding the importance of vaccination before the onset of dialysis and renal transplantation, to suggest that this vaccine should be available at various private and government hospitals at low prices than its original price and to evaluate the effectiveness of the awareness program on vaccinations among chronic kidney disease patients. Here the problem is that many patients belonging to lower socioeconomic status can not afford this costly vaccine and many patients are not aware of this vaccination needed in chronic kidney disease before starting of dialysis, because of lack of education or no any such information received from health care professionals. Hence it__ampersandsignrsquo;s essential to create awareness regarding vaccination among chronic kidney disease patients to reduce morbidity and mortality.