Platelet-rich fibrin is the most innovative __ampersandsignamp; commonly applied platelet concentrate in dentistry. Several modifications come across but injectable platelet-rich fibrin (i-PRF) showed unique properties. The objective of all this innovation is to find out all the components from the autologous blood to elucidate healing __ampersandsignamp; application in tissue engineering. These i-PRF has achieved predictable and effective results. The main difference of i-PRF from solid PRF is the lower speed and time in centrifugation for i-PRF. i-PRF is the liquid variety of PRF which may accelerate the wound-healing processes with increased vascularization. The benefits of i-PRF show slow and sustained release of growth factors, by releasing the expression of transforming growth factor-__ampersandsignbeta; and collagen-1 mRNA along with cells migration. The use of platelet aggregates in injectable form is commonly used in orthopaedics and plastic surgeries. Because it is autogenous, it decreases the chances of adverse reactions to the implanted material as compared to other ways of grafting which facilitate better option in regenerative procedures. It has been observed that i-PRF found to be effective in periodontal wound healing and bone regeneration. This review article focuses on the current status of i-PRF formulation advantages and uses in regenerative surgery along with the healing process.