Aim and Objectives: To review the current state of the knowledge about the COVID-19 cytological aspects. Background: The coronavirus disease 2019 (COVID-19) is a pandemic caused by the SARS-CoV2 virus. The infection has a predominantly respiratory transmission and it is transmitted through large droplets or aerosols, and less commonly with the infected surface or fomites. The widespread infection led to social distancing measures. Because it__ampersandsignrsquo;s miles brought about by a singular virus, the cutting-edge pandemic has created plenty of anxiety, a good deal of it because of the comprehensible fear of the unknown. We do no longer know how lengthy this pandemic will last, and what its toll on groups will be in terms of fatalities, or in psychological, physical, and economic well-being. At this time, we still have many unanswered questions about this virus. For a number of these questions, we won__ampersandsignrsquo;t have answers primarily based on hard information for months to come, maybe until the epidemic is over and an analysis of the worldwide records may be performed. Nonetheless, even before we have all the answers, we should neither panic, nor deal with it too lightly. We have to __ampersandsignldquo;hold calm and bring on__ampersandsignrdquo; and hold to characteristic as a cytology laboratory committed to offering the exceptional provider to our sufferers in this health care emergency, however at the same time maximize the protection of fitness care people and prevent useless risks, which could help the dissemination of the virus. Due to repeated exposure to infectious patients and specimens, health care workers and laboratory personnel are more susceptible to COVID-19. Discussion and Conclusion: This review paper provides an assessment of the current state of knowledge about the disease, its pathology, and the potential presence of the virus in the cytology samples. It also discusses the measures to be taken in the cytology laboratory during the pandemic and reduces the risk of the pathologist, personnel, and trainees.