Aim: The aim of the study is to analyze various preventive measures implemented to the public in the prevention and control of the spread of COVID-19. Methods: A systematic search strategy was employed using keywords to search the literature in various medical databases like PubMed and Google scholar using keywords COVID-19, Prevention, Transmission, Symptoms, and Treatment. Over 80 articles were collected and reviewed thoroughly. Discussion: Coronavirus disease 2019 (COVID-19) is an illness caused by a novel coronavirus, now called Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-Cov-2). Prevention and control strategies and methods are in three levels: national level, case-related population level, and general population level. Patients with COVID-19 have symptoms of fever, dry cough, and tiredness and series symptoms are shortness of breath. Infection prevention and control measures that can reduce the risk of exposure of the COVID-19 include the use of face mask, covering coughs and sneezes with tissue paper, regular hand wash, avoiding contact with infected people, and not touching your eyes, nose, and mouth frequently. Restrict your travel to many states and stay home, except to make essential trips to the grocery store, and pharmacies. Masks are recommended as a potential tool when it comes to tackling the COVID-19 pandemic since the initial outbreak in China. Masks are also being used by blocking droplets ejected by the wearer thereby acting as source control. In the absence of a vaccine or effective antiviral drugs, hand hygiene may be a mainstay of efforts to stop the spread of severe acute respiratory syndrome coronavirus-2 (SARSCoV-2), the virus that causes COVID-19. Conclusion: The only way to control is to prevent and control the spread, by physical distancing, facial mask, and use sanitizer