Introduction: Immunopathogenesis is the process of the development of a disease that involves immune response or immune system. The focus of the study is basically on the understanding of control and management along with the role-play of host immune responses and the pathogenesis of the microorganism. Coronavirus (CoV) is a large family of viruses which will lead to mild to severe illness, with symptoms most commonly cough, cold, and fever. The severe forms include Middle East Respiratory Syndrome (MERS-CoV) and Severe Acute Respiratory Syndrome (SARS-CoV). The worldwide pandemic COVID-19 was started in Wuhan city. Wuhan city, located in the Hubei province has a huge market called Huanan Seafood market housing numerous non-vegetarian foods which has now become the place where the pandemic started. A new strain of the virus that had not been earlier detected in humans is the Novel coronavirus (nCoV). These ranges of viruses are known to be zoonotic in nature, which means they can be easily transmitted between animals and human patients. The significant challenge faced with these viruses is their evolutionary nature. Materials and Methods: This is a review article wherein various articles were searched through search engines like Google Scholar and Pubmed using keywords like pathogenesis of COVID-19, immune mechanism of COVID-19, the role of TNF-Alpha, interferons, and diagnosis of COVID-19. Over 50 articles were collected and reviewed thoroughly. Results and Discussion: The nCoV is made up of a special protein called the glycosylated protein, which is also called the Spike protein or S protein. It plays a vital role in allowing the entry of viruses into the host cell. The spike protein is a large type 1 transmembrane protein that contains a range of 1160 amino acids. Spike protein is a trimeric class one fusion protein that exists in a metadata level perfusion. The ectodomain of all coronaviruses is known to share the same organization in two domains: an N-terminal domain called S1 that is responsible for receptor binding action and a C terminal S2 domain which is responsible for fusion. This review will give details of the molecular immunopathogenesis of COVID-19.