Introduction: COVID-19 (SARS-CoV-2) is a disease caused by the newly discovered novel Coronavirus. The first case of SARS-CoV-2 was reported in Wuhan, China in December 2019 which later turned out pandemic affecting large population across the world till now. Aim: This study aimed to review morphological differences of SARS-CoV-2 with other viruses belongs to beta coronaviruses and to analyze the effect of various factors on the spread of disease. Conclusion: SARS-CoV-2 causes a severe acute respiratory illness with morbidity rate up to 3%. Despite 79% similarity with SARS-CoV, key differences have been observed in spike glycoprotein, 2 accessory proteins and 2 non- structural proteins (nsp). High transmissibility of SARS-CoV-2 across the globe may be associated with these genetic differences. However, geographical differences in cases also suggest the influence of natural immunity, climatic conditions on disease spread. Unavailability of an effective vaccine and antiviral therapy left only social distancing and lockdown as an option to minimize disease spread. Further investigations are needed to know the mode of transmission, resistance to environmental factors. The developments of vaccine for SARS- CoV-2 in many countries are in Phase II __ampersandsignamp; III of clinical trial whereas many drugs have been repurposed to check their efficacy in combating SARS- CoV-2 infections. .