Introduction: In the medical curriculum of undergraduate and postgraduate medical students, the sound knowledge of anatomy forms the cornerstone for the foundation of medicine. Due to the budding of many medical colleges and increased demands of cadavers in medical colleges, voluntary body donation programmes have gained more importance in our country. Aim/Objective: To assess and compare the knowledge and attitude of medical and engineering students on voluntary body donation. To determine and compare the knowledge and attitude of medical and engineering students on various ethical issues associated with voluntary body donation. Material and Methods: This study was conducted on consented 75 medical students(8th and 9th terms) and 75 (final year) engineering students by distributing structured questionnaires covering the various ethical principles involved in body donation such as vulnerability, informed consent, autonomy, dignity, confidentiality and post act benefit. The obtained data were analyzed through descriptive statistics. Result: The data analysis showed that there is a difference in the knowledge, attitude and ethical perception of body donation among the students of both the groups. Conclusion: A comprehensive understanding of ethical and legal issues associated with the procurement of cadavers and its dissection is very important for the successful outcome of voluntary body donation programmes. Hence this study to assess the level of knowledge and attitude of medical and engineering students about voluntary body donation with special emphasize on ethical issues associated with body donation such as vulnerability, informed consent, dignity, autonomy, confidentiality, post act benefits.