Introduction: In the 1950s, Poliomyelitis was a dreaded disease which crippled millions of children all over the globe and a public health scare even in countries where the best health systems existed1 . Almost all children infected with polio developed paralytic poliomyelitis. Aim: This review aims to systematically review the published literature regarding the use of OPV and IPV at birth to determine; i) The justification for an additional dose of tOPV at birth. ii) The use of bOPV in place of tOPV. iii) The use of IPV in place of OPV. Conclusion: The lack of robust data at present does not recommend the birth dose of IPVin countries using IPV in their routine immunization schedule or any other countries.