Background: Extrapyramidal signs are side effects of antipsychotic medications when the patient is receiving Schizophrenia treatment. Such signs include dystonia (continuous spasms and muscle contractions), akathisia (may manifest as muscular restlessness), Parkinsonism (characteristic signs such as stiffness), bradykinesia (slow motion), tremor, and intermittent dyskinesia (irregular, jerky motion). Aim: This case report aims to identify extrapyramidal symptoms at the earliest, prevent potential harm and to provide quality of nursing care to the patients. Objectives: 1. To identify extrapyramidal symptoms by the nurses and to report immediately. 2. To take action immediately and to prevent adverse effects. Results: The patient was taking Tab. Olanzapine 20mg for 25 years, abruptly stopped the medicine without consulting to the psychiatrist and the patient started with abnormal movements of lips, head and neck for two days. The patient was treated with Tab.Pacitone12 mg, movements were minimized. Conclusion: The nurses play a vital role at the bedside and take care of psychiatric patients when they receive antipsychotic drugs.