Introduction: Novel Coronavirus is a single-stranded RNA Viruses infected by Severe Acute Respiratory Syndrom-Coronavirus-2 (SARS-CoV-2) which is first reported on Wuhan, China on January 7, 2020, and spreading all over the world rapidly. The new virus is threatening the whole world and the world is scared in front of the virus. WHO declared the outbreak as a pandemic on March 11, 2020. Report: It is reported that the viral infection is transmitting via airborne from human to human or animal to human. Pneumonia, cough, sneezing, cold and respiratory disease are the main symptoms of this viral infection. Unfortunately, there are no vaccines or clinically proved antiviral drugs for COVID-19. So we should strictly keep social distance and should maintain personal hygiene. It is better to identify the active cases as soon as possible and isolate the infected ones to break further spreading. Conclusion: In this review, we are discussing the background, etiology, transmission, clinical symptoms, Risk factors, treatment and preventive methods against COVID-19