Background and Aim: Postoperative pain relief following Laprascopic cholecystectomy is a major concern as it may affect functional outcome. The present study was conducted to compare the analgesic efficacy of ropivacaine and bupivacaine as an intraperitoneal Instillation during laparoscopic cholecystectomy under general anaesthesia and during the post-operative period. Material and Methods: Sixty patients were allocated meeting the necessary criteria were divided equally into two groups(30 per group) to receive either 20 ml 0.5% ropivacaine (Group A) or 0.5% bupivacaine(Group B) Instillation intraperitoneally at the end of surgery. The patients were given rescue analgesia when visual analogue scale (VAS)was more than or equal to 4 and/or visual rating scale (VRS) was more than or equal to 3. The primary objective was to compare VAS and VRS and rescue analgesic requirement. Secondary objectives were to assess post-operative adverse effects and complication if any. Results: The mean VAS score and VRS score were comparable in both groups. Bupivacaine provides a slightly longer duration of analgesia and on other had Ropivacaine has higher safety profile at higher doses. Both have similar rescue analgesic doses and in systemic safety profile at this concentration. Conclusion: Bupivacaine or ropivacaine in equal volume and concentration instilled intraperitoneally at the end of surgery in patients undergoing laparoscopic cholecystectomy shows comparable efficacy in relieving post laparoscopy pain especially in early postoperative hours.