Introduction: A surgical incision may be all the provocation bacteria need for the battle to begin. Notwithstanding the advances made in pre-employable asepsis, clean procedures, and prophylactic anti-toxins, patients exposed to tasks normally need to confront the danger of complexities. Aim: Study was aimed at the evaluation of antibiotic usages in surgical cases. Methods: A serial study of 200 patients was done who have undergone operative procedure due to some surgical problem, under the Department of Surgery. Results: Overall incidence of postoperative wound infection in this study is 31%.70% of wound infections occur above the age of 50 years. malnutrition (41.30%) and obesity (50%) have a higher SSI rate than that of averagely nourished patients (28.16%). The number of patients encountered in this study suffering from diabetes was 15. Conclusions: Infection rate rises with increasing degree of operative contamination; Risk of wound infection in elective and clean surgeries is airborne or endogenous, while in other categories The age of the patient exerts a direct influence on the occurrence of postoperative wound infection, Sex of the patient is apparently and indirectly related to the risk of infection, The rate of postoperative wound infection increases with poor nutritional status, poor hygiene and low socioeconomic status. To reduce the infection rate, nutritional status and hygiene of the patient should be improved, at least in elective surgical procedures.