Aim: Body mass index (BMI) is an important parameter in gauging adiposity and obesity. Many studies have shown higher incidence of cardiovascular diseases especially coronary artery diseases in population with BMI greater than 25. (1) Studies also reveal median and ulnar nerve compression associated with an increasing incidence of higher BMI. (2) This study is an attempt to establish a relationship between median nerve conduction parameters and BMI in a population group from a metropolitan city in urban India. Methodology: In the present study the effect of Body Mass Index (BMI) on Median nerve motor and sensory conduction latency, amplitude and velocity was analysed in 90 healthy people in the age group of 18-30 years. Standardized protocol was followed while performing nerve conduction study in all the subjects. Results: This study shows that sensory nerve conduction amplitude decreases significantly with increase in BMI whereas the effect on other parameters is non-significant. Conclusion: This could be attributed to attenuation in conduction current by thicker subcutaneous tissue in persons with higher BMI. Median nerve latency and conduction velocity do not show significant decrease. This could be due to the fact that speed of conduction is same in the fastest conducting fibres irrespective of the adiposity..