Background: Within weeks of the emergence of the novel coronavirus COVID-19 in China, misleading rumors and conspiracy theories about the origin circulated the globe paired with fear-mongering, racism, and mass purchase of face masks, all closely linked to the new __ampersandsignldquo;infomedia__ampersandsignrdquo; ecosystems of the 21st century marked by social media. The impact of media reporting and public sentiments may have a strong influence on the public and private sectors in making decisions on discontinuing certain services including airline services, disproportionate to the true public health need. Analyses of discussions on social media with regards to the epidemic situation geographically and over time can result in real-time maps. Such real-time maps could be used as a source of information on where to intervene with key communication campaigns. Aim: Aim of the study is to analyze the role of social media in COVID-19. Materials and Methods: A cross-sectional survey was initiated in Coimbatore and Chennai districts of Tamil Nadu about knowledge, awareness, and perception in the role of social media. Results and Discussion: Nearly 100 people responded. The survey data has been collected and with the help of SPSS software, data has been analyzed and plotted as a graph. Conclusion: At the end of the study, people were somehow aware of the current status of COVID-19 and they have gained knowledge of the control and prevention of COVID-19 through social media.