Background: Sickle cell anaemia has a high prevalence in India, especially in the central and western regions like Jharkhand, Bihar, Maharashtra, and Madhya Pradesh and poses a considerable health burden. Dr. Bhosale says that in Maharashtra, most patients are either from Nagpur, Wardha, or the Amravati belt. While the sickle cell mutation was first observed in South India among the tribal groups, the condition afflicts both tribal and non-tribal populations. Objectives: 1. To assess the knowledge regarding sickle cell anaemia among newly married couples in a rural area. 2. To associate knowledge regarding sickle cell anaemia among newly married couples with selected demographic variables. Materials and Methods: This study was based on a descriptive research design. The population was the newly married couple from the Wardha district. The subject consisted of 50 newly married couples of 1-2 years, in the selected community of Wardha district. Results: According to information regarding sickle cell anaemia reveals that 86% of their husband and 64% of the wife had information about sickle cell anaemia and remaining need not have any information. Conclusion: This study concluded after analysis that males are having more knowledge than females regarding sickle cell anaemia among newly married couples.