Background: The TTK Chitra mechanical heart valve prosthesis (CHVP) is a mono-leaflet, tilting disc design heart valve, which was developed in India and relatively cheaper than western Mechanical Prosthetic valve. Very limited studies are available for the comparison of CHVP versus western mechanical prosthetic heart valve. This study was designed to compare the Indian valve vs. western valve. Methods: It was a single centre, retrospective-prospective follow-up study. The study was approved by the Institutional Ethics Committee(Ethical clearance was not required) and written informed consent was obtained from all participants. Among records of the hospital management system 531 medical records screened, 378 subjects met the inclusion-exclusion criteria and were included for analysis. SPSS software was used for analysis. Results: The results of this study indicate that the long term performance of the St. Jude Mechanical heart valve and TTK Chitra mechanical valve prostheses is comparable in terms of clinical benefits, adverse events and mortality. Conclusions: The CHVP offers equivalent results at almost half the cost of an imported St Jude Mechanical heart valve making the prospect of cardiac surgery available to a large number of deserving patients in resource-limited settings.