This study attempted to learn about students__ampersandsignrsquo; experiences as they encounter problems in the team-based simulation learning process, specifically when they interact with asthmatic patients during clinical trials involving hybrid model methods, asthma standardized patients, and human patient simulators. Aim and Scope: Thus, in this study, nursing students had the opportunity to experience a theoretical knowledge of asthma and direct nursing for patients with diseases through team-based learning courses. Method: The team-based simulation learning method using these hybrid models is believed to be a useful foundation for improving students__ampersandsignrsquo; knowledge, interacting with colleagues, and confidence in practice. Conclusion: It is judged that the team is engaged in clinical practice with the process of expanding the thinking and human relationships, and self-examination, while engaging in the learning experience of the team for simulation of asthma patients.