Introduction: Breast malignancy is a significant general medical issue for women all through the world. In the United States, breast malignant growth remains the most incessant disease in ladies and the second most frequent cause of cancer death. Methods: Fifty cases of carcinoma of the breast in which tumour markers were studied All the cases were admitted in this institution, investigated and treated accordingly but tumour marker was sent to the outside standard laboratory, Mumbai. The cases were followed up, for a minimum period of 24 months. Results: In 13/24 cases with abnormal CA15-3 value in postoperative follow up period, there are 54% of patients with metastatic disease. In 4/24 cases with preoperative abnormal CA15-3, metastasis occurred in 75% and locoregional recurrence occurred in 50%. In 8/50 cases with preoperative abnormal CA15-3, 75% of patients are presented with locally advanced disease. In 9/24 cases with abnormal CEA value in the postoperative follow-up period, there are 67% of patients with metastatic disease. In 15/24 cases with preoperative abnormal CEA, metastasis occurred in 40% and In 16/24 cases with preoperative abnormal CEA, locoregional recurrence occurred in 25%. In 32/50 cases with preoperative abnormal CEA, 63% of patients are presented with locally advanced disease. Conclusions: There is the significance of Tumour markers in carcinoma of the breast. The use of CA15-3 for early detection of metastasis seems to be promising. It appears that CA15-3 is a valuable prognostic indicator in following up of breast cancer patients as it had a significant association with both metastases and loco-regional disease.