Introduction: The high plasma or serum concentrations of total homocysteine are associated with an increased risk of atherothrombotic disease. Aim- a study to assess Plasma Homocysteine Concentration in Acute Coronary Syndromes. Methods: Total 60 patients with the diagnosis of coronary artery disease and non-hemorrhagic stroke are included in this study. Results: In the present study, the plasma homocysteine level is significantly elevated in patients with CAD and non-hemorrhagic stroke. The elevated plasma homocysteine level is an independent and traditional risk factor for CAD. This is turn may revolutionise the development of new strategies of treatment for primary prevention of CAD and non-hemorrhagic stroke in those individuals who do not have traditional risk factors. In absence of the established major atherogenic risk factors like hypertension, diabetes mellitus, hyperlipidemia and smoking, atherosclerotic occlusive vascular events are known to occur. This indicates that there may be an additional independent risk factor such as elevated plasma homocysteine. There is increasing evidence that, linked hyperhomocysteinaemia as a risk factor for the pathogenesis of atherosclerosis. To confirm this concept, 60 cases of occlusive atherosclerotic vascular events (45 coronary artery disease and 15 non-haemorrhagic cerebrovascular diseases), without other risk factors are studied, for plasma homocysteine levels. Conclusion: Homocysteine levels are studied in control subjects without clinical vascular diseases. The data is analysed to demonstrate the correlation of homocysteine levels with vascular events.