Aim: The study was conducted to assess the awareness among parents especially the mothers regarding liquid medication among children and its relation to caries progression. Materials and Method: Around 230 mothers were included in the study. The mothers were asked to fill a validated questionnaire and her offspring were assessed for presence or absence of dental caries. Results: The data revealed that 80.4% of mothers preferred medication in syrup form, 63.5%administered medication twice daily while none of the mothers performed oral hygiene measures post medication. Around 78.7% of mothers were unaware of the relation between liquid medication and caries. Conclusion: The Pediatric dentists should create awareness among the mothers regarding liquid drug administration and oral hygiene measures.