Background: Type 2 Diabetes Mellitus is a clinical condition that is associated with energy metabolism, particularly carbohydrate and fat management in the organism. An increase in the prevalence of diabetic population and the association of decreasing patient compliance and medication adherence leads to prefer a new concept for the management of disease complications. The use of complementary and alternative medicine (CAM) has proved to be effective for controlling diabetes. Objectives: The purpose of this review is to perform an overview of CAM use, to emphasize its importance for managing diabetic complications and to get outfits of CAM. Discussion: A literature survey was done by using various articles related to CAM and Diabetes mellitus. The focus was kept on the frequency of CAM use, the methods they use, the factors related to the use of CAM, the sources of information about CAM treatment, and the effect of the method used for disease management. Conclusion: This review concluded that CAM therapy found to have adept at reducing blood glucose, maintaining a healthy body, and relieving symptoms of DM. From the study, the relevance of CAM for managing Diabetic complications was verified and the future need to perform scientific researches on CAM use was analyzed.