Introduction: Acute obstructive bronchitis is a widespread disease among children, leading to frequent relapses and complications. This pathology occupies one of the leading places in the structure of childhood morbidity and mortality. Analysis of risk factors in predicting the likelihood of acute obstructive bronchitis in children is essential for modern pulmonology. Acute pneumonia in patients with acute obstructive bronchitis occurs 4 times more often and almost always has a complicated course. When exposed to an infectious factor and other agents, various immunological changes are observed in children and the body__ampersandsign#39;s ability to develop a full-fledged post-infectious immunity is sharply reduced. Result: We examined 65 children with acute obstructive bronchitis and 35 children with acute simple bronchitis without obstruction at the age of 3 months. up to 3 years. Children with acute obstructive bronchitis were at the age of 6 months. up to 3 years old, of which 39 (60%) were boys, 26 (40%) were girls. Immunological research was carried out in the clinical laboratory of the clinic of the Samarkand Medical Institute. The number of T-lymphocytes, T-helpers, T-suppressors, as well as B-lymphocytes, was determined by a modified method. The concentration of serum immunoglobulins A, M, G in peripheral blood was determined by the method of Mancini et al. Phagocytic activity of neutrophils was studied using latex particles. The first group of patients was on traditional treatment with the inclusion of T-activin, and the second group of children was only on traditional treatment. Conclusion: Dynamic immunological study revealed a decrease in factors of phagocytic activity of neutrophils, cellular immunity and developing transient insufficiency of humoral immunity with an increase in the duration of the disease.