Introduction: Heart failure (HF) is a global problem, with more than 20 million people affected. The overall prevalence of heart failure in developed countries is around 2%. The significance of natriuretic peptides (NPs) is well established in the diagnosis of heart failure (HF). Materials and Methods: In this cross-sectional study, 100 consecutive patients who presented with acute dyspnea to the Emergency department of a tertiary medical centre in Palakkad were included from December 2019-April 2020. The initial diagnosis for dyspnea was assigned to the emergency department. Later the patient was evaluated in the cardiology department and a final diagnosis was made. A rapid microparticle enzyme immunoassay (AXSYM SYSTEMS ABOTT) was used for the quantitative determination of BNP measurement. EDTA plasma of the patients was subjected to the estimation of BNP according to the manufacturer__ampersandsignrsquo;s instructions. Results: Out of 100 patients, 79 % had abnormal BNP levels (__ampersandsigngt;100pg/ml); Out of these,6 In this study, among patients with elevated BNP levels 55 % had abnormal ECG changes and 45 % had normal ECG 1% (n=47) were diagnosed to have CCF(p__ampersandsignlt;0.01) and 39% had another diagnosis. Conclusion: The results conclude that the measurement of BNP levels will help the clinicians to differentiate cardiac and noncardiac causes of dyspnea in the emergency setting.