Objective: The objective was to formulate gliclazide (GLZ) fast disintegrating tablets (FDTs) by using fenugreek seed mucilage and Celosia argentea powder as natural disintegrating agents as well as sodium starch glycolate as a synthetic disintegrating agent. Experimental: An attempt was made to extract the fenugreek seed mucilage and prepare the C. argentea powder and evaluated both for various physicochemical characterizations. FDTs of GLZ were formulated by direct compression method using different concentrations (3-7% w/w) of fenugreek seed mucilage and C. argentea powder and compared with synthetic disintegrating agent sodium starch glycolate. The formulated tablets were evaluated for various physical tests like weight variation, friability, hardness, etc. and the complied results fall with the limits. Results: Among all the formulations, F9 containing 7% C. argentea powder produced the least disintegrating time of 19 sec resulting in a higher drug release rate of 98.13% at the end of 60 min. C. argentea powder as a natural disintegrant showed better disintegrating property than the most widely used synthetic disintegrant sodium starch glycolate in the formulations of FDTs. Conclusion: The study concluded that C. argentea powder will act as a good disintegrating agent and it may be believed to exhibit promising additive anti-diabetic activity with GLZ.