Introduction: Aim of our study is to assess the efficacy of intravenous ketamine to control the postoperative pain in patients who have undergone appendicectomy. Methods: A total of 50 adult patients who were undergoing surgical intervention for acute appendicitis were examined and evaluated. They were randomly divided into two groups. In 25 cases (test group) after spinal anaesthesia and level of anaesthesia fixed at T4, 0.5 mg/kg of ketamine was given along with butorphanol, midazolam and glycopyrrolate, 10 mins before surgical incision. While in rest of 25 cases (control group), the same anaesthesia technique was used but intravenous ketamine was not given before pneumoperitoneum. The severity of pain was evaluated at 0 hrs (just after arousal), 4 hrs, 12 hrs and 24 hrs after surgery using 10 points visual analogue scale (VAS). Results: The VAS score was remarkably lower in the study group as compared to the test group for all the time durations postoperatively. Also, there was no drug interaction or side effect observed in test subjects. Conclusion: Preemptive administration of low dose ketamine has a phenomenal effect on the reduction of postoperative pain after appendicectomy.