Introduction: Treatment of arterial hypertension in type 2 diabetes mellitus patients is complex and at the same time, according to our data, possible and/or controlled process. For example, the use of combined antihypertensive therapy of enalapril with moxonidine is effective in the treatment of arterial hypertension in patients with type 2 diabetes, which has a positive effect on the dynamics of catecholamine excretion and 3,4-dioxyphenylalanine, monoamine oxidase activity, significantly reduces the level of Malone dialdehyde in serum. Aim and Objective: After combined hypotensive therapy with moxonidine, we observed a more pronounced statistically significant decrease in daily excretion of CA and DOFA, with values of these indicators approaching those of the control group. Result: Thus, after treatment with moxonidine, there was a significant decrease in SBP by 28.5%, DBP by 11.2% (P __ampersandsignlt;0.001), possibly due to suppression of the SAS functional activity.