Introduction: Most of previous studies on E-cigarette were focused on adolescents and adults or factors related to the use of E-cigarette. The relationship between E-cigarette selection factors and smoking cessation attempts among college students has not been reported yet. Objective: The objective of this study was to analyze the relationship between perception of E-cigarette and smoking cessation attempts in college students known to have strong mental and physical maturity, social justice, and ideals compared to adolescents and have strong desire. This study used data from the Korea National Health and Nutrition Examination Survey in 2016. Subjects were 36 college students enrolled in school who had E-cigarette experience. Linear regression analysis was performed to identify factors influencing smoking cessation using SPSS version 25.0. Result: Regarding factors influencing smoking cessation, both model 1 and model 2 revealed that those who perceived E-cigarette to __ampersandsign#39;help quit smoking and be less harmful than cigarette__ampersandsign#39; were more likely to have cessation attempt. In Model 2, frequency of binge drinking was more likely to affect smoking cessation in __ampersandsign#39;less than 4 times a month__ampersandsign#39; compared to __ampersandsign#39;more than 4 times a month__ampersandsign#39;. Conclusion: A health policy should be established so that continuous smoking cessation support services can be provided to college students along with a healthcare approach to disseminate proper awareness of E-cigarette