Background: Pregnancy-induced hypertension (PIH) is a leading cause of high-risk pregnancy and is detrimental to both mother and the child. Hence this study was undertaken to study the effect of magnesium sulfate combined with calcium channel blocker in the management of pregnancy-induced hypertension. Methodology: A total of 120 pregnant women admitted with PIH in the Department of OBGY in a tertiary hospital from October 2019 to April 2020 were randomly divided into the control group (60 cases) and the observation group (60 cases). The observation group was treated by magnesium sulfate along with a calcium channel blocker; i.e. nifedipine, while the control group was treated by only magnesium sulfate. Results: The 120 patients were divided into 2 groups of 60 each and the effective rate of the observation group was 95%, higher than 81.67% of the control group, and the difference was statistically significant (P__ampersandsignlt;0.05). Both systolic and diastolic blood pressure in the observation group were found to be decreased which was better than that in the control group, and the difference was statistically significant (P__ampersandsignlt;0.05). Conclusion: PIH can be more effectively managed by a combination of Magnesium sulfate with a CCB like nifedipine.