Background and Objective: Good health is an important prerequisite for growth of any organisation. Health-related quality of life (HRQOL) is an important outcome of health. Any adversity in health such as musculoskeletal disorders (MSD) will affect HRQOL. Modern defence system has significant role of electrical, electronic and Instrument technicians in armed forces. Despite their intensive role, little is known about MSDs __ampersandsignamp; HRQOL in these technicians. Method: 164 Electrical, telecom and instrument technicians were assessed for MSDs and HRQOL, using Nordic Musculoskeletal Questionnaire (NMQ) and RAND 36-Item Health Survey 1.0. All eight domains of HRQOL were compared for personnel having MSDs with those who were unaffected. Effect of MSDs and its symptomatology was assessed on physical component score (PCS), mental component score (MCS) and __ampersandsignlsquo;Well being__ampersandsignrsquo; scores of HRQOL using logistic regression. Results: High prevalence of MSDs (73.45%) and negative effect of MSDs on all domains of HRQOL was noted. Though presence of MSDs, multiple MSDs, increase frequency and severity of pain negatively affected PCS, MCS was affected only with increased frequency of pain. MSD, frequency and severity of pain had significant negative impact on Well-being. Conclusion: There is high prevalence of MSDs among light maintenance defense personnel and these MSDs have adverse effect on HRQOL. We suggest regular screening and suitable preventive/therapeutic measures to control the occurrence and its symptoms, thereby maintaining optimum HRQOL.