Amavata is a disease in which vitiation of Vata Dosha and accumulation of Ama take place in joint(s), and it simulates rheumatoid arthritis (RA) at modern phraseology. Shamana (conservative) and Shodhana (biological purification of the body) treatments are advised in Ayurveda whereas anti-inflammatory, analgesics, steroids, and disease modifying antirheumatic drugs are required for its management as per modern medicine, which is not free from side effects. The symptoms of Amavata are alike to Rheumatism, which include Rheumatoid arthritis and Rheumatic fever. It is observed that Rheumatism is an autoimmune disorder, which is among the collagen disorders having strong and significant parlance with Amavata. A variety of drug trials were already carried out on Amavata, yet there is a lacuna in the management of Amavata. Hence the present study was designed to calculate the effectiveness of Ayurvedic formulations in Amavata. The study was conducted in 15 clinically diagnosed cases of Amavata (Rheumatoid Arthritis) with objectives of Clinical Evaluation of Therapeutic Effect of Rasnadikashayam 3 t.s.f. thrice/day, Sahachradikashayam 3 t.s.f. once/day, Amvatari Ras 2 tabs once/day were given for 3 months and Erand tail __ampersandsignfrac12; t.s.f.once/day at night were given for 1 month along with Swedan therapy in patients of Amavata (Rheumatoid Arthritis) on the basis of various scientific parameters. Patients were treated with the whole therapeutic regime mentioned in Ayurvedic classics i.e., Langhana, Swedana, use of Tikta, Katu, and Deepan dravyaprayoga, Virechan. The effect of the therapy was assessed by a specially prepared proforma and at the end of the treatment, 39.39% improvement was observed in the overall effect of therapy. Paired t-test was applied to this BT and AT scores as these grades is accepted as per international norms. It showed that administered therapy reduced the degree of disease activity significantly as P __ampersandsignlt; 0.001.