Aim: To study the FSHR gene (Ser680Asn) polymorphism in women with the polycystic ovarian syndrome (PCOS) __ampersandsignamp; healthy controls and to correlate with hormonal parameters. Methodology Design __ampersandsignamp; Setting: Hospital-based Cross-sectional observational Study Patients: 30 diagnosed cases of PCOS and 30 age-matched healthy controls. Main Outcome Measure(s): FSHR gene (ser680asn) polymorphism genotype, Hormonal Levels: FSH, LH, Prolactin, Testosterone, DHEAS Results: LH, LH: FSH ratio and Testosterone levels were found to be significantly higher in women with PCOS compared to their healthy counterparts (p-value__ampersandsignlt;0.001). No significant difference was seen in the genotypic distribution of the FSHR gene (ser680asn) polymorphism between cases and controls. Inter-genotypic variation of FSH levels was observed in cases, with the GG genotype (9.21__ampersandsignplusmn;1.07 IU/L) showing significantly higher levels compared to AG genotype (5.78__ampersandsignplusmn;0.46 IU/L) with a p-value of 0.024. Conclusion: The FSHR gene (ser680asn) polymorphism does not show any differential distribution between PCOS and healthy women. FSH levels, however, are influenced by the FSHR gene (ser680asn), as the serine variant of the polymorphism has higher FSH levels compared to the asparagine variant. This polymorphism could contribute to the flawed folliculogenesis in PCOS.