Methicillin-resistant Staphylococcus aureus (MRSA) infection remains the ever-increasing health care problem. It brings a high rate of morbidity and mortality especially in immunocompromised and hospitalised patients. MRSA infection is most often severe due to the expression of virulence factors, toxins, and immune-modulatory gene products along with limited options for its treatment. MRSA in the healthcare settings is an emerging challenge. Exposure of healthcare personnel to the MRSA environment puts them at increased risk of acquiring the infection. Given the limited options for treatments, there is a need to cautious use the current treatments and quest for research and development of new anti-MRSA agents. For the prevention of MRSA infection in healthcare personnel, adequate implementation of infection and prevention strategies is essential in all healthcare settings. In this article, we discussed the epidemiology of MRSA, current and emerging treatment options along with infection control strategies in the healthcare settings.