Objective: 1. To estimate the amount of patient exposed to NSAID i.e. Diclofenac and opioid i.e. Tramadol and towhat extent drugs are properly used, overused. 2. Our thesis aimed to provide a comparative overview of NSAID__ampersandsign#39;s analgesic efficacy i.e. Diclofenac, i.e. Opioids Tramadol and aimed at evaluating which type of drug is ideally suited in our Emergency Department (ED) for pain relief in acute renal colic. Methods: The study was planned as a prospective observational study conducted in Ureteric colic Patients receiving analgesics Tramadol and diclofenac in their management. Diagnosis was established by non-contrast abdominal CT. Fifty patients were selected for the study, of which 28 were given Diclofenac and 22 Tramadol. Data was analysed by using Microsoft excel sheet and descriptive statistics. Results: Characteristics of patients such as average stone size and degree of hydronephrosis at the time of enrolment were close to those of previous investigations. Diclofenac was slightly more effective in minimizing pain intensity at 30 minutes as calculated on a 10 cm visual analog scale than Tramadol. A reduction in pain frequency of over 50 per cent was reported in 56 per cent of patients diagnosed with Diclofenac and 44 per cent of patients treated with Tramadol (P __ampersandsignlt; 0.05). Further Tramadol community patients required analgesia for the release (p__ampersandsignlt;0.05). Taking into fact all the study variables, Diclofenac has an enhanced analgesic efficacy than Tramadol in all aspects. Conclusions: The drug Diclofenac i.e. NSAID is more effective than Tramadol i.e. OPOID, as a single agent for treating ureteric colic patients. Tramadol can be an option in situations where contraindications prohibit Diclofenac from being used.