Background: Sepsis is a leading cause of mortality and is a major cause of morbidity by causing end-organ damage as well as cognitive and physical disability in survivors. Sepsis can be defined as the presence (probable or documented) of infection together with systemic manifestation of infection. Patients with sepsis generally have multiple predisposing factors and sources of infection. Cardiac dysfunction adds up in increasing the mortality rate in patients with sepsis. Diastolic dysfunction can predict long term mortality and morbidity in sepsis and is recognized to be a major cause of heart failure with normal ejection fraction (LVEF__ampersandsigngt;55%). Material and Methods: The study was done on subjects admitted in ICU under the department of Medicine. All patients above 18 years, those who gave their consent for the study or their relatives, also fulfilled the criteria for sepsis as mentioned in guidelines for sepsis. Though the calculated sample size with 50% proportion of sepsis in two years was 127, this study included 140 patients. Worst APACHE II scores were calculated during the period of admission within the first 24 hours. All the pathological and biochemical parameters were measured by standard laboratory techniques. Blood pressure was measured using a mercury sphygmomanometer, using a Riva-Roci cuff in the right hand in the supine position. Worst APACHE II score was calculated in the first 24 hours for the sepsis patients admitted in the Medicine intensive care unit and was interpreted. Results: In the present study on 140 patients, the mean age of patients was 50.15__ampersandsignplusmn;16.37 years. This study population was male dominant where 94 (67.14%) were males and 46 (32.86%) were females. Out of the total study population, 104 (74.3%) were survivors while 36 (25.7%) were non-survivors. Worse APACHE II score from 20 to 34 had a greater number of patients with left ventricular diastolic dysfunction. When the APACHE II score was correlated with the presence of LVDD in both survivors and non-survivors, it was observed that in the non-survivors as the APACHE II score worsens from 20 to 34, there was significant mortality as compared with the survivors. Conclusion: LVDD was present in patients above the age of 40 years. As the APACHE II score worsens from 20 to 34, a greater number of patients showed LVDD. When APACHE II score was correlated with presence of LVDD in both survivors and non-survivors, it was observed that in the non-survivors as the APACHE II score worsens from 20 to 34 and there was a significant mortality as compared with the survivors.