This study analyzed the morphological properties of cytosporosis disease in the Reinette Simirenko variety (Malus) of apple trees and nature of its damage to the causative agents in the Lower Amudarya region (Uzbekistan). The region is characterized with dry climate and shallow groundwater tables which can effect on the spread of the disease. For determining the causes of the disease, the apple trees and the groundwater level were monitored in orchards where the cytosporosis diseaseis widespread. Based on thismonitoring and additional correlation analysis, we found out considerable influence of the groundwater level in the expansion of cytosporosis in apple orchards.