Background: Dyspnea is a common symptom in hospitalized adult patients and is among the most serious, as it is often a harbinger of severe pathology. Prevalence of dyspnea varies among clinical settings and patient subgroups; in the community 3% to 25%, outpatient clinics 3.7%, emergency rooms 2.7%, and at hospital admissions 15% to 25%. The study of clinical and laboratory profiles of dyspnea patients is essential for a community practice. Objectives: 1. To study the clinical profile of acute dyspnea patients 2. To evaluate the underlying etiopathology of acute dyspnea Materials and Methods: This observational study was be conducted at K.V.G. Medical College __ampersandsignamp; Hospital, Sullia on 150 subjects from March 2016 __ampersandsignndash; Dec 2016. Result: In the present study, 43 patients had fever, 132 patients had cough, 127 patients had sputum, 11 patients had Hemoptysis, 52 patients had PND, 34 patients had chest pain and 8 patients had syncope as a presentational symptom. Mean heart rate was 111.38/min, SBP was 135.36 mmHg, DBP was 88.85 mmHg, Respiratory rate was 29.48/min. Sp02 was 88.91. Analysis of ECG showed, 24 patients (16.00%) had LVH,29 patients (19.33%) had ST Elevation, 12 patients (8.00%) had T wave inversion, 12 patients (8.00%) had LAD, 34 patients (22.67%) had RAD, 6 patients (4.00%) had CHB, 4 patients (4.00%) had LBBB,17 patients (11.33%) had RBBB. 48 patients (32%) had cardiomegaly, 23 patients (15.33%) had pleural effusion,18 patients (12 %) had consolidation. Patients diagnosed with DKA had mean Ph of 7.11, Pco2 of 21.1 mmHg, and HCO3 of 9.62 mEq/Lit. When compared, patients diagnosed with Acute exacerbation of COPD and Asthma had mean pH of 7.21, Pco2 of 60.83 mmHg, and HCO3 of 24.7 mm/l. 30 patients (20.00%) were diagnosed with Acute exacerbation of COPD, 14 patients (9.33%) were diagnosed with Acute exacerbation of Asthma, 22 patients (14.67%) were diagnosed with Pneumonia, 3 patients (2.00%)were diagnosed with Pulmonary embolism, 11 patients (7.33%) were diagnosed with Pleural effusion, 6 patients (4.00%) were diagnosed with Pneumothorax, 24 patients (16.00%) were diagnosed with Acute on chronic CCF, 31 patients (20.67%) were diagnosed with MI with CCF,4 patients (2.67%)were diagnosed with DKA, 2 patients each (1.33%) were diagnosed with Uremic encephalopathy and Hepatic encephalopathy each, 1 patient. (1.33%) was diagnosed with psychogenic dyspnea. Acute exacerbation of COPD had mortality of 11.76%, Acute exacerbation of Asthma had a mortality of 13.33%, Pneumonia had a mortality of 13.64%, Pulmonary embolism had a mortality of 33.33%, Pleural effusion had a mortality of 16.67%, Pneumothorax had a mortality of 50%, Acute on chronic CCF had a mortality of 25.00%, MI with CCF had a mortality of 28.13 %, DKA had a mortality of 25.00%. Overall mortality was 20.67%. Conclusion: The study concluded that Pneumothorax had the highest mortality (50%) followed by pulmonary embolism (33.33%) and MI with CCF (28.13%). Uremic encephalopathy, Hepatic encephalopathy and psychogenic dyspnea had the least mortality.