Background: Acute liver failure (ALF) is an entity with rapid deterioration of liver functions which is associated with increased morbidity and mortality. Methods: Data recorded in terms of aetiology, complications, prognostic factors and mortality predictors in a defined period of January 2018-January 2019. Univariate analysis was done to compare several parameters of survivors and expired patients and then all significant parameters were fed into a sequential logistic regression analysis to determine independent parameters of prognosis. Results: A total of 100 patients [56 males and 44 females: age (mean __ampersandsignplusmn; SD) 30.13 __ampersandsignplusmn; 13.32 years] with acute liver failure were enrolled in the study. Among these, 70 (70%) patients died due to the development of complications. In this study acute liver failure was caused by Hepatitis E virus in 44(44%) patients, hepatitis A virus in 19 (19%), hepatitis B virus in 10 (10%), hepatitis C virus in 2 (2%), and hepatitis non A to E in 17(17%). The number of female patients was 44of which, 35 were in childbearing age, 24 (68.57%) were pregnant and 20(83.33%) were in the third trimester. Hepatitis E was found positive in 22 (91.66%) pregnant women. Conclusion: Hepatitis E was found as the commonest cause of acute liver failure and also in most of the pregnant women, mostly in the third trimester were affected. Initial bad prognostic indicators were non-hepatitis E aetiology, prothrombin time __ampersandsigngt;30 s, coma grade __ampersandsigngt;2 and age __ampersandsigngt;40 years.