Aim: More than 150 known factors associated with ILD and prevalence are uncommon with usual clinical presentation of exertional dyspnea and cough, with finding on examination often limited to fine inspiratory crackles on auscultation.Diagnosis can be made by combination of clinical, radiological and pathological features. Methods: This is a prospective study constituting 60 cases of ILD conducted to study the cardiovascular dysfunctions associated with interstitial lung diseases with special reference to serum NT PRO BNP and microalbuminuria as bio-markers of cardiovascular dysfunction and co-relating the level of serum NT PRO BNP and microacclbuminuria with echocardiographic, bronchoscopic and HRCT findings in ILD patients. Results: When the correlation between major 2D Echo findings, raised serum NT PRO BNP and microalbuminuria was made it was found that out of total 24 cases of PAH all 24 cases(100%) had raised serum NT PRO BNP and 23 cases(95.83%) had microalbuminuria, out of total 8 cases of diastolic dysfunction all these 8 cases(100%) had raised serum NT PRO BNP and 4 cases(50%) had microalbuminuria, out of 26 cases of normal 2D Echo 4 cases(15.38%) had raised serum NT PRO BNP and 2 cases(7.69%) had microalbuminuria. Result: Pulmonary hypertension is a very important predictor of mortality; early detection can help in inducting early intervention and can delay mortality. Hence 2D Echo, serum NT Pro BNP and microalbuminuria evaluation should be included in the evaluation of all ILD cases.