Introduction: The first rib is the most curved rib and very distinct from other ribs. The significant landmarks on the first rib include the head, tubercle, vascular groves on the superior surface and the scalene tubercle. Anomalous ribs are often discovered incidentally on chest radiographs. Such anomalies, maybe associated with the compression of the neurovascular bundle at the root of the neck. Further research on the first rib may also yield information that substantiates the growing relevance of first rib in sex identification and age estimation, particularly when the skull and pelvis are damaged to a significant extent. Objectives: This study aims to analyze the morphological and morphometrical variations of first rib and understand the significance of such variations. Materials and Methods: 35 right and 35 left first ribs were used for the purpose of this study. All the measurements were taken with digital Vernier calipers and flexible cloth tape. The findings were recorded and analyzed statistically. The study was conducted in Department of Anatomy, M. S. Ramaiah Medical College, Bengaluru. Results: As far as the morphological parameters were concerned, scalene tubercles were either absent or rudimentary in nearly 50% of the ribs on both right and left sides. Similarly, vascular grooves were either absent or insignificant in approximately half of the ribs on both right and left sides. The variations of the head and the tubercle of the first rib were not encountered frequently. Conclusion: Malformations of the first rib are common. When present, it may lead to compression of neurovascular bundle at the root of the neck causing thoracic outlet syndrome. Awareness of such anomalies are important for anatomists, radiologists and thoracic surgeons dealing with this region.