Introduction: Hypothyroidism is mainly caused due to deficiency of hormones. It is categorised into congenital and acquired depending on the level of endocrinal dysfunction in primary and secondary or central and the severity of severe or clinical hypothyroidism and mild or subclinical. Method: 50 Women with hypothyroidism and 50normal healthy individuals were included in the present hospital-based case control study with proper inclusion and exclusion criteria. BMI and their relationship with Central Hypothyroidism were estimated using different methods with proper handling of samples. Result and Observation: The mean value of T3, T4, TSH were more in control as compared to cases and this difference was significant. Correlation between TSH and BMI was positive and highly significantat p__ampersandsignlt;0.01 level of significance and negative correlation between T4 and TSH which was significant as p__ampersandsignlt;0.05. Conclusion: Finding of present study indicates that there is positive correlation between TSH and BMI, which is highly significant at 0.001 level and negative correlation between T4 and TSH which is significant as p__ampersandsignlt;0.05. Thus, we conclude there is a strong positive relationship between BMI and hypothyroidism.