The Sushruta Samhita (classical text) is one of the three great treatises (Brihattrayi) of Ayurveda representing mainly the school of surgery. Sushruta Samhita (classical text) is the best one in Sharira (Anatomy). The term sira (blood vessel) is as old as Vedas. In Ayurveda, the term sira (blood vessel) has been used for blood vessels. Angiology is the division of modern anatomy and it deals with different types of blood vessels of the body. The ancient texts of Ayurveda have mentioned sira (blood vessel), dhamani (artery) and srotas (capillary) are interchangeable words and these terms are equal to blood vessels in modern anatomy. According to Ayurveda, the term sira (blood vessel) reflects different modern anatomical terms like blood vessel, vein, and nerve. Therefore, it requires great research work to get a clear concept. The main aim of this work is to understand the concepts of sira (blood vessel) in Ayurveda and its correlation with modern angiology.