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<article xlink="http://www.w3.org/1999/xlink" dtd-version="1.0" article-type="healthcare" lang="en"><front><journal-meta><journal-id journal-id-type="publisher">IJCRR</journal-id><journal-id journal-id-type="nlm-ta">I Journ Cur Res Re</journal-id><journal-title-group><journal-title>International Journal of Current Research and Review</journal-title><abbrev-journal-title abbrev-type="pubmed">I Journ Cur Res Re</abbrev-journal-title></journal-title-group><issn pub-type="ppub">2231-2196</issn><issn pub-type="opub">0975-5241</issn><publisher><publisher-name>Radiance Research Academy</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">2684</article-id><article-id pub-id-type="doi"/><article-id pub-id-type="doi-url">http://dx.doi.org/10.31782/IJCRR.2020.12113</article-id><article-categories><subj-group subj-group-type="heading"><subject>Healthcare</subject></subj-group></article-categories><title-group><article-title>Coagulation Profile in Liver Disease&#13;
</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Rupela</surname><given-names>Chetali</given-names></name></contrib><contrib contrib-type="author"><name><surname>Vaghela</surname><given-names>Bhavika</given-names></name></contrib><contrib contrib-type="author"><name><surname>Goswami</surname><given-names>Hansa</given-names></name></contrib></contrib-group><pub-date pub-type="ppub"><day>3</day><month>06</month><year>2020</year></pub-date><volume>1)</volume><issue/><fpage>18</fpage><lpage>20</lpage><permissions><copyright-statement>This article is copyright of Popeye Publishing, 2009</copyright-statement><copyright-year>2009</copyright-year><license license-type="open-access" href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.</license-p></license></permissions><abstract><p>Background: The liver is the cornerstone of the coagulation system. The physiology of blood coagulation is closely linked to liver function as the liver synthesizes most of the factors of the coagulation cascade and fibrinolytic proteins.&#13;
Aims And Objectives: The objective of this study was to evaluate coagulation abnormalities associated with chronic liver diseases and determine the coagulation abnormalities using various coagulation studies PT (Prothrombin time), APTT (activated partial thromboplastin time).&#13;
Material and Methods: This study included 50 patients clinically diagnosed with liver disease and who were divided into three categories __ampersandsignndash; cirrhosis, hepatitis, and other liver diseases.&#13;
Results: Out of 45 patients with liver disease, 39 were having altered coagulation profile and 28 were having altered biochemical parameters.&#13;
Conclusion: We concluded that various abnormalities of coagulation tests vary greatly with different liver disorders, duration of the disorders, and their severity. Prolongation of prothrombin time (PT) and activated partial thromboplastin time (APTT) in advancing liver cirrhosis indicates damage to the liver parenchyma resulting in decreased production of coagulation proteins with increased risk of bleeding tendencies, which can be detected before these ensue.&#13;
</p></abstract><kwd-group><kwd>PT</kwd><kwd> APTT</kwd><kwd> Liver Disease</kwd></kwd-group></article-meta></front></article>
