MPV measures the average size of platelets and is an emerging risk factor of atherosclerosis. The functions of platelets include adhesion, shape change and spreading, aggregation, secretion, procoagulant activity and clot retraction. Mean Platelet Volume can be simply analyzed by the ABX pentra automated analyzer using electrical impedance. There are many markers of atherosclerosis. The present study aims to find a correlation of MPV with Total Cholesterol, LDL, HDL,VLDL,Triglyceride. Aims and Objectives: To determine the correlation between MPV and Lipid Profile ( Total cholesterol,LDL,HDL,VLDL,Triglyceride) Materials and methods: 150 patients of Department of General Medicine participated in the study. The patients were selected by simple random sampling. Inclusion and exclusion factors were considered. Patients above 18 years of age were selected. Patients taking medications that reduce platelets, alcoholics and those having hereditary disorders of large platelets were excluded. Results: MPV is inversely correlated with HDL . Thus methods applied to increase HDL in general population will lead to decrease in MPV and lower risk of atherosclerosis. There is a positive correlation of MPV with VLDL and Triglyceride, but the correlations are not statistically significant. There is a negative correlation of MPV with LDL and Total Cholesterol, but the correlations are not statistically significant.