Background: Vaspin is a visceral adipose tissue-derived serine protease inhibitor. Previous data suggest that vaspin may be involved in the glucose metabolism and the development of T2DM in humans. Objectives: This study is intended to compare the serum vaspin and atherogenic propensity by comparing fasting plasma glucose, post-prandial plasma glucose, lipid profile, atherogenic index and BMI with Ox-LDL level as a marker for cardiovascular risk between diabetic patients and non-diabetic subjects. Material __ampersandsignamp; Methods: This study was conducted with 120 newly diagnosed type 2 diabetes mellitus (T2DM) patients with age-matched 120 non-diabetic subjects as controls. Results: We found that there is significant increase in the parameters like serum Vaspin, FPG, PPPG, lipid profile (Total Cholesterol, Triglycerides __ampersandsignamp; Very low density lipoprotein), Oxidized-Low density lipoprotein level and Atherogenic index (TC/HDL). No significant differences were found between BMI, LDL __ampersandsignamp; HDL parameters of T2DM patients compared to non-diabetic subjects. The results have been shown positive correlation (P?0.01) between Vaspin with BMI and LDL while negative correlation (P?0.01) was observed between Vaspin with FBS, PPBS, Ox-LDL __ampersandsignamp; VLDL in T2DM patients. Conclusion: Our results indicate that circulating Vaspin and Ox-LDL are potential new independent CVD risk biomarker in T2DM.