Angiogenesis is a very important process in the progression of the tumor growth. Vascular endothelial growth factor (VEGF) is a key factor in angiogenesis. The main function is vascular permeability, angiogenesis and endothelial cell growth. An inactivated or impaired tumor suppressor gene Von Hipple Lindaue(VHL) causes accumulation of hypoxia inducible factor (HIF-1A) and leads to increased production of VEGF. The more the expression of VEGF, the worse is the survival and recurrence in many malignancies like Renal Cell Carcinoma. VEGF-targeted therapy plays a major role in various carcinomas involving VEGF pathway for their cancerous growth.__ampersandsignnbsp;