Sulforaphane is a compound that is correlated to the iso-thiocyanate family.It is well studied to be anti-carcinogenic preventing stomach cancers, antimicrobial, anti-inflammatory and neuroprotective in addition to its sufficient ability to protect against aging and diabetes. Sulforaphane reveals a direct positive effect on the intestinal tissues as it shows a sufficient ability in presenting a high antimicrobial respond that leads to the prevention of uprising various bacteria including both the gram-positive and the gram-negative ones such as Escheria coli and Helicobacter pylori in addition to other types of bacteria. The main objective of this study is to report a profound review of the recent papers done on this topic in order to clarify the relationship between the sulforaphane and intestine. For this review, however, there are no many articles that indicate the intimate relation, ten articles and reports from PubMed and Google Scholar databases have been included in this review of literature in order to demonstrate sulforaphane and its functions and effects towards the intestinal flora. This updated literature synthesis compromised that sulforaphane has a direct positive influence on the intestinal flora. Thus more attention should be put into consideration regarding the increase of its intake.__ampersandsignnbsp;