The replacement of dilapidated or already extracted first permanent molars (FPMs) is the subject of multidisciplinary discussion. Many treatment options are considered to restorate a dilapidated FPM like: crown restoration after an endodontic treatment or, replace an exAtracted FPM like: space maintainer or orthodontic treatment for space closure. This case-report described another alternative of treatment in which spontaneous space closure (SSC) is obtained after extraction of first permanent molars in mixed dentition. Indeed, if some conditions are reunited, the SSC by the eruption of the second permanent molars, which will take up