Summary Genomics is a discipline in genetics that applies recombinant DNA technology, DNA sequencing methods and bioinformatics to sequence, assemble and analyze the function and structure of genome, the complete set of DNA within a single cell of an organism. Bioinformatics is an inter-disciplinary scientific field that develops methods for storing, retrieving, organizing and analyzing biological data. The advances in bioinformatics have in turn made considerable impact on the development and improvements of genomics technologies such as shot-gun sequencing and high-throughput sequencing methods. The various genomics technologies are used for DNA and genome sequencing, assembly and annotations, which have several applications in medicine, agriculture, pharmaceuticals, biotechnology, research etc. These genomics technologies aided by bioinformatics have contributed to the successful completion of whole organism genome analysis, from prokaryotes to eukaryotes. In fact, the assembly of the human genome is one of the greatest achievements of bioinformatics.