Background: Pelvic organ prolapse is a latent disease that may take origin after injury of the connective tissue. This investigation aims to compare the surgery outcome of the Laparoscopic High Uterosacral ligament suspension (LHULS) and the Laparoscopic Sacrocolpopexy (LSC). Materials and Methods: This is a retrospective study. Fifty-three participants with pelvic organ prolapse stage __ampersandsignge;II referring to pelvic organ prolapse quantification (POP-Q) system were desirable in this study. Thirty participants underwent LSC, twentythree others experienced the LHULS surgery. The surgery outcomeand patient__ampersandsignrsquo;s satisfaction were assessed by the POP-Q system, and the pelvic floor questionnaires PFDI-20, PFIQ-7, PISQ-12, respectively. Whitney-Test was utilized to analyze the pre-and post-operative results between groups, while the Wilcoxon signed rank test was used to compare the pre-and postoperative outcomes. Result: The POP-Q score improved significantly for both groups postoperatively. LSC was superior to LHULS in the anterior compartment, the postoperative mean for Ba was (2.54 __ampersandsignplusmn;0.56 Vs -2.39__ampersandsignplusmn; 1.47). The LSC was superior to The LHULS in the posterior compartment as well; Bp(2.50__ampersandsignplusmn; 1.96 Vs-2.08__ampersandsignplusmn;1.3, P__ampersandsignlt;0.05). The LHULS had a higher patient satisfaction especially in urinary symptoms (P__ampersandsignlt;0.05). The LSC has a longer operation time and inpatient day, as well as an extended catheterization time (P__ampersandsignlt;0.05). Moreover, the LSC has a higher amount of bleeding and a higher occurrence of hysterectomy (P__ampersandsignlt;0.05). Conclusion: The LSC technique demonstrated his superiority in anterior and posterior compartment than LHULS. The LHULSsurgery had a higher patient satisfaction for urinary symptoms.The LSC has a longer operation time and in-patient day compared to LHULS.